Advanced glycation end products (AGEs) are synthesized via the non enzymaticglycation and oxidation of proteins,
lipids and nucleic acids. The production of AGEs is particularly enhanced in chronic hyperglycemia, as in diabetes
mellitus (DM). The formation of irreversible AGEs affects the tissues by compromising the physiologic and mechanical
functions, as a result of defective constitution of the extracellular matrix (ECM) components. Periodontitis is an inflammatory
disease of microbial origin, resulting in devastation of the tooth supporting apparatus. This disease condition has
severe implicationsin subjects with DM, since the tooth supporting tissuescontain ECM targeted by AGE. There is miniscule
literature regarding the contribution of AGE to periodontal disease in patients with DM. The purpose of this review is
to address the prejudicial role of AGEs in relation to various tissue components. This paper is an attempt to elucidatethe
possible link of AGEs between periodontitis and DM. The exploration of novel therapeutic strategies to target AGEs for
the treatment of periodontitis in DM subjects is certainly intriguing.
Keywords: Advanced glycation end products, diabetes mellitus, inflammation, oxidative stress, periodontitis, receptor for advanced
glycation end products.
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