Effects of Senna didymobotrya Root Extract and Compounds on Tritoninduced Hyperlipidaemic Rats and Differentiation of 3T3-Li Preadipocytes

Author(s): Charles O. Ochieng, Atul Shrivastava, Upma Chaturvedi, Ravi Sonkar, Ashok K. Khanna, Gitika Bhatia, Rakesh K. Asthana, Philip O. Owuor, Lawrence A. Manguro, Anil K. Saxena

Journal Name: The Natural Products Journal

Volume 3 , Issue 3 , 2013

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The lipid lowering effects of Senna didymobotrya (Leguminoceae) root extract (250 mg/kg) and pure isolates (100 mg/kg) were investigated for hypolipidemic activity on Triton-induced hyperlipidemic rats (in-vivo). The extracts and isolates showed significant (p≤0.01) reduction in serum lipid contents, and reactivation of the lipolytic enzymes, relative to the Triton-treated group. Ethyl acetate extract exhibited the highest lipid lowering (p≤0.01) compared to other fractions. Seven anthraquinones, obtusifolin (1), 1,6-di-O-methylemodin (2), nataloemodin-8-methyl ether (3), chrysophanol (4), physcion (5), chrysophanol-10,10'-bianthrone (6), physcion-10,10-bianthrone (7) and stigmasterol (8) were isolated from the ethyl acetate extract. Compounds 3, 5 and 7 displayed significant (p≤0.01) lipid lowering effects. The hypolipidaemic activities prompted the determination of inhibition of differentiation of 3T3-L1 preadipocytes into adipocytes by the compounds 3, 5 and 7. Only compound 7 exhibited potent anti-adipogenic activity without significant cytotoxicity. The result indicated that extracts of S. didymobotrya root extract can provide good antidyslipidaemic and adipocytes maturation inhibitors.

Keywords: Adipogenesis, antioxidants, hyperlipidaemia, leguminocea, senna didymobotrya.

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Article Details

Year: 2013
Page: [212 - 217]
Pages: 6
DOI: 10.2174/22103155113039990011
Price: $25

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