Total Tannin Content and Antidiarrheal Activity of Tecomaria capensis Leaves Extract

Author(s): Neeraj Kumar Saini, Manmohan Singhal, Anshumali Awasthi, Gautam Mishra

Journal Name: The Natural Products Journal

Volume 3 , Issue 3 , 2013

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Purpose of the research: Ethnopharmacological survey indicated that leaves decoction of Tecomaria capensis (Thunb.) Spach (Bignoniaceae) was used in the treatment of diarrhea and intestinal inflammation. To confirm this activity, estimation of Total tannin content and evaluation of antidiarrheal potential of methanol Tecomaria capensis leaves extract (denominated TCLE) were performed.

Major Findings: Acute toxicity study showed that no mortality and toxicity were found in animal until 14 days. TCLE showed that it contained high quantity of tannins. TCLE showed significant and dose-dependent inhibition of diarrheic defecations, intestinal transit and antienteropooling effect at doses 100, 200 and 500 mg/kg p.o.

Conclusion: This study supports previous claims regarding its ethnopharmacological use in treatment of diarrhea

Keywords: Diarrhea, Intestinal inflammation, gastro-intestinal tract, loperamide, atropine sulphate, bignoniaceae.

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Article Details

Year: 2013
Published on: 01 August, 2013
Page: [218 - 223]
Pages: 6
DOI: 10.2174/22103155113039990005
Price: $25

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