Abstract
A plenitude of reasons, including tumour heterogeneity, mechanisms of resistance to therapy, a complex pathogenesis, in which cancer stem cells are involved, contribute to the poor outcome of HNSCC patients after therapy. The roles of vital signalling proteins are constantly unravelled, and different types of inhibitors are examined yielding novel potential targeting strategies. However, there will be a long way to go, before drugs targeting these molecules will be available in routine clinical practice. In this review the focus will be on these novel targets, as well as inhibiting agents, which nowadays are combined to an increasing degree. Additionally, the role proteomics plays in modern drug research will be highlighted.
Keywords: Cancer stem cells, epithelial-to-mesenchymal transition, HNSCC, proteomics, targeted therapy.
Current Proteomics
Title:Novel Agents Targeting Crucial Signalling Pathways in Head and Neck Squamous Cell Carcinoma, HNSCC - Preclinical Development and Data from Clinical Trials
Volume: 10 Issue: 2
Author(s): Eva-Maria Schottdorf
Affiliation:
Keywords: Cancer stem cells, epithelial-to-mesenchymal transition, HNSCC, proteomics, targeted therapy.
Abstract: A plenitude of reasons, including tumour heterogeneity, mechanisms of resistance to therapy, a complex pathogenesis, in which cancer stem cells are involved, contribute to the poor outcome of HNSCC patients after therapy. The roles of vital signalling proteins are constantly unravelled, and different types of inhibitors are examined yielding novel potential targeting strategies. However, there will be a long way to go, before drugs targeting these molecules will be available in routine clinical practice. In this review the focus will be on these novel targets, as well as inhibiting agents, which nowadays are combined to an increasing degree. Additionally, the role proteomics plays in modern drug research will be highlighted.
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Schottdorf Eva-Maria, Novel Agents Targeting Crucial Signalling Pathways in Head and Neck Squamous Cell Carcinoma, HNSCC - Preclinical Development and Data from Clinical Trials, Current Proteomics 2013; 10 (2) . https://dx.doi.org/10.2174/1570164611310020007
DOI https://dx.doi.org/10.2174/1570164611310020007 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
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