Pluronic-Based Core/Shell Nanoparticles for Drug Delivery and Diagnosis

Author(s): Yon Woo Jung, Hwanbum Lee, Jae Yeon Kim, Eun Jin Koo, Keun Sang Oh, Soon Hong Yuk

Journal Name: Current Medicinal Chemistry

Volume 20 , Issue 28 , 2013

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Pluronic-based core/shell nanoparticles (NPs) were formed using various strategies such as self-assembly and temperature induced-phase transition. To improve their functionality as a nanomedicine for diagnosis and therapy, the vesicle fusion and layer by layer approach were employed. Because of the hydrophilic nature of the Pluronic shell and the relatively small size, Pluronic-based core/shell NPs were used in order to improve their pharmacokinetic behaviors in drugs and in imaging agents. This review will introduce various types of Pluronic-based core/shell NPs according to their preparation method and formation mechanism. The focus will be on the Pluronic-based core/shell NPs for tumor targeting, stimulated release of proteins, and cancer imaging capabilities.

Keywords: Antitumor efficacy, cancer targetability, chitosan/heparin composite, core/shell nanoparticles, enhanced permeability and retention effect, layer-by-layer approach, molecular imaging agent, Pluornics, Pluronic/liposome composite nanoparticles, polyethylene glycol, protein drug, self-assembly, temperature-induced phase transition, vesicle fusion.

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Article Details

Year: 2013
Page: [3488 - 3499]
Pages: 12
DOI: 10.2174/09298673113209990036
Price: $65

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PDF: 43