Functional Role of miR-34 Family in Human Cancer

Author(s): Rui Wang, Jia Ma, Qiong Wu, Jun Xia, Lucio Miele, Fazlul H Sarkar, Zhiwei Wang

Journal Name: Current Drug Targets

Volume 14 , Issue 10 , 2013

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Recently, microRNAs (miRNAs) including miR-34 family have been found to play a critical role in tumorigenesis through regulating the expression of its target genes, which are involved in many cellular processes such as cell proliferation, survival, apoptosis, migration, invasion and angiogenesis. Thus, this review described the role of miR-34 family and how its deregulation is involved in the development and progression of human malignances. Moreover, we described the potential role of miR-34 as a novel biomarker for tumor diagnosis. Furthermore, we summarized that miR-34 family could be up-regulated by natural compounds in human cancers. Therefore, targeting miR-34 family could be a novel strategy for achieving better treatment outcome of cancer patients in the future.

Keywords: miR-34, cancer, natural compound, oncogene, therapy, tumor suppressor gene.

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Article Details

Year: 2013
Published on: 30 June, 2013
Page: [1185 - 1191]
Pages: 7
DOI: 10.2174/13894501113149990191
Price: $65

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