Genistein Down-Regulates miR-223 Expression in Pancreatic Cancer Cells

Author(s): Jia Ma, Long Cheng, Hao Liu, Jing Zhang, Ying Shi, Fanpeng Zeng, Lucio Miele, Fazlul H Sarkar, Jun Xia, Zhiwei Wang

Journal Name: Current Drug Targets

Volume 14 , Issue 10 , 2013

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Although genistein has been shown to inhibit tumorigenesis in a variety of human cancers including pancreatic cancer (PC), the exact molecular mechanism of its anti-cancer effects has not yet been fully elucidated. Recently, microRNAs (miRNAs) have been reported to regulate multiple aspects of tumor development and progression, indicating that targeting miRNAs could be a novel strategy to treat human cancers. In the current study, we investigated whether a natural compound genistein could down-regulate onco-miR-223, resulting in the inhibition of cell growth and invasion, and induction of apoptosis in PC cells. We found that genistein treatment significantly inhibited miR-223 expression and up-regulated Fbw7, one of the targets of miR-223. Moreover, down-regulation of miR-223 inhibited cell growth and induced apoptosis in PC cells. These findings suggest that genistein exerts its anti-tumor activity partly through downregulation of miR-223 in PC cells.

Keywords: miR-223, Fbw7, apoptosis, cell growth, genistein, pancreatic cancer.

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Article Details

Year: 2013
Page: [1150 - 1156]
Pages: 7
DOI: 10.2174/13894501113149990187
Price: $65

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