Title:Michael Addition-initiated Sequential Reactions from 1,3-dicarbonyls for the Synthesis of Polycyclic Heterocycles
VOLUME: 17 ISSUE: 18
Author(s):Xavier Bugaut, Damien Bonne, Yoann Coquerel, Jean Rodriguez and Thierry Constantieux
Affiliation:Aix Marseille Universite, CNRS, iSm2 UMR 7313, 13397, Marseille, France.
Keywords:Consecutive reactions, Domino reactions, Multicomponent reactions, Michael addition, Polycyclic heterocycles, 1, 3-Dicarbonyl
compounds.
Abstract:This review aims to highlight the most significant recent developments on synthetic strategies involving consecutive, domino
and multicomponent reactions featuring a Michael addition-initiating step for the synthesis of polycyclic heterocycles from 1,3-
dicarbonyls. These original sequences constitute more efficient and eco-compatible alternatives to known synthetic approaches to heterocyclic
compounds allowing for an even faster and highly desirable generation of molecular diversity and complexity.
