Sympathetic Overactivity in Hypertension and Cardiovascular Disease

Author(s): Manolis A.J., Poulimenos L.E., Kallistratos M.S., Gavras I., Gavras H.

Journal Name: Current Vascular Pharmacology

Volume 12 , Issue 1 , 2014

Become EABM
Become Reviewer
Call for Editor


From the first description of its anatomy by T. Willis to the novel therapeutic manipulations, it is unanimously recognized that the sympathetic nervous system (SNS) holds a crucial role in cardiovascular homeostasis. The introduction of sophisticated techniques, as microneurography and regional norepinephrine spillover provided the evidence for the role of sympathetic overactivity in various cardiovascular disease entities. Sympathetic activation is common in patients with essential hypertension and contributes to initiation, maintenance and progression of the disease and it contributes to the manifestation of its major complications. A considerable body of evidence relates SNS overactivity with high sodium intake in experimental animals and humans and the underlying mechanisms have nowadays been elucidated. SNS activity is more pronounced in patients with resistant hypertension and there are several conditions that lead to this phenomenon, as older age, kidney disease, obesity and metabolic syndrome, mental stress and sleep apnea. SNS overactivity holds also a key physiopathological role in heart failure, acute coronary syndromes and arrhythmias. Moreover, inhibition of sympathetic overactivity by various means, including central SNS suppressing drugs, peripheral alpha- and beta- adrenergic receptor blockers, or novel approaches as renal sympathetic denervation have been used successfully in the treatment of all these disorders.

Keywords: Sympathetic nervous system, sympathetic overactivity, microneurography, noradrenaline spillover, hypertension.

open access plus

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2014
Published on: 30 July, 2013
Page: [4 - 15]
Pages: 12
DOI: 10.2174/15701611113119990140

Article Metrics

PDF: 121