Active quassinoids extracted from Brucea javanica seeds were tested for their activities against Tobacco
mosaic virus (TMV). Results from activity-guided assays indicated that the compounds can reduce the replication of the
virus by up to 98.5% (50 µg/mL). The active quassinoids inhibit the replication of TMV genomic and subgenomic RNAs
and the synthesis of TMV coat protein in vivo but did not destroy the integrality of the virus. Structure-activity relationship
(SAR) analysis indicated that the positions of the furan ring, the α,β-conjugated ketone, and integrity of the A ring
had significant impacts on the antiviral activity of quassinoids.
Keywords: Simaroubaceae, Brucea javanica, quassinoids, inhibition, TMV, SAR.
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