Recent Development of New Substituted Indole and Azaindole Derivatives as Anti-HIV Agents

Author(s): Sureyya Olgen

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 13 , Issue 12 , 2013

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Human immunodeficiency virus-1 (HIV-1) infections cause global health problems. Indole derivatives have been considered as one of the promising HIV inhibitors. Recent inventions have focused on substituted indole and azaindole derivatives that possess unique antiviral activities against HIV-1. In this review, the evaluation of recent advances in substituted indole and azaindole derivatives for the treatment or prevention of HIV-1 and acquired immune deficiency syndrome (AIDS) has been focused. In this respect, compounds having drug and bio-active properties, including their synthesis and pharmacologic properties have been reported. In addition, anti-HIV properties of compounds, the structural features of inhibitors, the current progress in terms of therapeutic interventions and the leading groups in the field are discussed. Moreover, clinical and ADME (Absorption, Distribution, Metabolism, Elimination) properties of some clinically important compounds such as BMS-378806, L-737126 and IDX899 are reported.

Keywords: Antiviral, Indole and Azaindole Derivatives, Synthesis, HIV, Clinical Studies.

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Article Details

Year: 2013
Published on: 31 August, 2013
Page: [1700 - 1708]
Pages: 9
DOI: 10.2174/13895575113139990075
Price: $65

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