Abstract
Nutrient perception in the gut is important for the maintenance of nutrient and energy balance in the body. Recently, nutrient perception has attracted the attention of medical researchers, as it may provide an opportunity to prevent obesity and associated disease. Recent progress in functional MRI (fMRI) techniques have enabled noninvasive investigation of whole brain function during the processing of information regarding ingested nutrients from the gut depending on the feeding status in both rodents and human subjects. However, the fMRI technique still has substantial problems because it relies on blood oxygenation levels. Here, a novel fMRI technique is introduced that solves this problem for rodent fMRI studies and fMRI studies of the gut-brain axis.
Keywords: Functional MRI, chemoreception, gastrointestinal tract, vagus nerve, gut hormone.
Current Pharmaceutical Design
Title:Neuroimaging of Gut Nutrient Perception
Volume: 20 Issue: 16
Author(s): Tomokazu Tsurugizawa
Affiliation:
Keywords: Functional MRI, chemoreception, gastrointestinal tract, vagus nerve, gut hormone.
Abstract: Nutrient perception in the gut is important for the maintenance of nutrient and energy balance in the body. Recently, nutrient perception has attracted the attention of medical researchers, as it may provide an opportunity to prevent obesity and associated disease. Recent progress in functional MRI (fMRI) techniques have enabled noninvasive investigation of whole brain function during the processing of information regarding ingested nutrients from the gut depending on the feeding status in both rodents and human subjects. However, the fMRI technique still has substantial problems because it relies on blood oxygenation levels. Here, a novel fMRI technique is introduced that solves this problem for rodent fMRI studies and fMRI studies of the gut-brain axis.
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Cite this article as:
Tsurugizawa Tomokazu, Neuroimaging of Gut Nutrient Perception, Current Pharmaceutical Design 2014; 20 (16) . https://dx.doi.org/10.2174/13816128113199990580
DOI https://dx.doi.org/10.2174/13816128113199990580 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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