Different cross-coupling reactions for the formation of biologically important motifs and intermediates in organic
synthesis using various suitable copper catalysts are reviewed. These include C-C, C-N, C-O, C-S heteroatom bond
forming, cyclization and other miscellaneous reactions catalyzed by elemental copper, copper salts, CuI, Cu (OTf)2, CuBr,
Cu2O etc. The use of copper reagents instead of palladium catalysts and ligands seems to be advantageous from the commercial
point of view. The methods described herein afford the products in excellent yield without using expensive and
moisture/air sensitive palladium catalysts, ligands and reagents.