Thyroid Cancer: A Clinical Overview and A Useful Laboratory Manual

Indexed in: Book Citation Index, Science Edition, EBSCO.

Thyroid nodules have a high prevalence in populations where iodine deficiency rates are high and in people older than 50 years. Considering that only 5-10% of thyroid nodules are of malignant nature, ...
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Potential Markers for the Diagnosis of Thyroid Cancer

Pp. 96-111 (16)

Silvia Cantara

Abstract

Some of the genetic alterations described in thyroid cancer, such as RET/PTC rearrangements, RAS point mutations and PAX8/PPARγ rearrangements, have also been found in benign lesions. The only exception is the point mutation V600E of BRAF oncogene, which is specific for the malignant histology. For this reason, researchers are seeking new markers expressed only by cancer tissues. Among these, telomerase activity and expression, together with miRNAs expression, have been proposed to be able to distinguish benign from malignant lesions both in tissues and FNAC samples with high specificity.

Keywords:

miRNA, molecular diagnosis, telomerase, telomere.

Affiliation:

Section of Endocrinology & Metabolism, Department of Internal Medicine, Endocrinology & Metabolism and Biochemistry, University of Siena, Siena, Italy.