Tyrosine Kinase Inhibitor and Target Therapy
Pp. 85-95 (11)
“Tyrosine kinase inhibitors” (TKI) are small molecules responsible for
selectively inhibiting cellular pathways involved in cell proliferation or migration.
These molecules have been developed as alternative therapy for refractory or minimal
responsive cancers to standard treatments. In this chapter, TKI currently used for
anaplastic thyroid cancer, medullary thyroid cancer and/or refractory differentiated
thyroid cancer will be described.
Tyrosine kinase, Tyrosine Kinase Inhibitors (TKI), growth factor
Section of Endocrinology & Metabolism, Department of Internal Medicine, Endocrinology & Metabolism and Biochemistry, University of Siena, Siena, Italy.