Thyroid Cancer: A Clinical Overview and A Useful Laboratory Manual

Indexed in: Book Citation Index, Science Edition, EBSCO.

Thyroid nodules have a high prevalence in populations where iodine deficiency rates are high and in people older than 50 years. Considering that only 5-10% of thyroid nodules are of malignant nature, ...
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Familial Non-Medullary Thyroid Cancer

Pp. 64-75 (12)

Stefania Marchisotta


Familial non-medullary thyroid cancer is a clear clinical distinct entity characterized by multifocality and a more severe phenotype and is defined as the presence of two or more first-degree relatives affected by differentiated thyroid cancer of follicular origin. In some cases, the disease is associated with rare hereditary syndromes such as Carney complex, Werner syndromes, FAP and Cowden syndromes. However, in the majority of the cases, patients have thyroid cancer as the only disease manifestation. Several studies have tried to identify the genetic alteration(s) responsible for the development of FNMTC with promising results although none of the genes/loci identified accounts for the majority of cases of FNMTC and cannot be generalized to the larger at-risk population.


FNMTC, Cowden disease, Werner syndrome, Carney complex, genetic loci.


Section of Endocrinology & Metabolism, Department of Internal Medicine, Endocrinology & Metabolism and Biochemistry, University of Siena, Siena, Italy.