Oncogenes Involved in Thyroid Cancer Development
Pp. 25-40 (16)
Indeterminate nodules at FNAC are usually candidates for surgical therapy,
but, at final histology, most of them are benign. An alternative to improve the
diagnostic accuracy of FNAC might be the identification of molecular alterations
characteristic of malignant thyroid nodules in the material obtained by FNA. To do that,
it is necessary to know which oncogene(s) are mainly involved in thyroid cell
transformation, the pathway(s) they stimulate and the mutation responsible for
oncogene(s) activation. These aspects will be discussed in this chapter.
BRAF, RAS oncogene, RET/PTC rearrangements, molecular
Section of Endocrinology & Metabolism, Department of Internal Medicine, Endocrinology & Metabolism and Biochemistry, University of Siena, Siena, Italy.