Thyroid Cancer: A Clinical Overview and A Useful Laboratory Manual

Indexed in: Book Citation Index, Science Edition, EBSCO.

Thyroid nodules have a high prevalence in populations where iodine deficiency rates are high and in people older than 50 years. Considering that only 5-10% of thyroid nodules are of malignant nature, ...
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Oncogenes Involved in Thyroid Cancer Development

Pp. 25-40 (16)

Silvia Cantara

Abstract

Indeterminate nodules at FNAC are usually candidates for surgical therapy, but, at final histology, most of them are benign. An alternative to improve the diagnostic accuracy of FNAC might be the identification of molecular alterations characteristic of malignant thyroid nodules in the material obtained by FNA. To do that, it is necessary to know which oncogene(s) are mainly involved in thyroid cell transformation, the pathway(s) they stimulate and the mutation responsible for oncogene(s) activation. These aspects will be discussed in this chapter.

Keywords:

BRAF, RAS oncogene, RET/PTC rearrangements, molecular diagnosis.

Affiliation:

Section of Endocrinology & Metabolism, Department of Internal Medicine, Endocrinology & Metabolism and Biochemistry, University of Siena, Siena, Italy.