This review article summarizes the recent information regarding general aspects in the automated synthesis of 18F-labelled
PET radiotracers that are prepared via nucleophilic fluorination pathway. The previous and on-going researches in development of different
automation solutions are discussed and the current trends in large scale production of radiotracers are considered. The advantages and
limitations of the fully automated systems available from different manufacturers are exemplified by routine automated production of
several clinically relevant 18F-radiotracers using traditional automated synthesizers, kit-based (cassette-type) radiochemistry modules and
Keywords: Automation, F-18, Nucleophilic fluorination, PET radiopharmaceuticals, Synthesis modules.
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