This paper revisits some aspects of carbon-11 radiochemistry from the production of the primary labeling reagents and fast
chemical transformations used to convert them into more useful building blocks such as [11C]methyl iodide and [11C]carbon monoxide.
The application facet covers traditional methylation, carboxylation and other reactions in the preparation of PET tracers. Technical aspects
and strategies in handling labeling syntheses are also included. Distinct attention is then given to methods for the 11C-labelling of
carbamide and carbamate functional groups at the carbonyl position, considering the wide choice of protocols and starting materials that
have become available for this purpose. Concluding sections provide an overview of contemporary practices for the purification of labeled
compounds and preventing their radiolytic decomposition.
Keywords: Carbon-11, Radiochemistry, Positron Emission Tomography, PET, Review.
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