Efficacy and Safety of Long Acting Injectable Atypical Antipsychotics: A Review

Author(s): Domenico De Berardis, Stefano Marini, Alessandro Carano, Antonella Padovan Lang, Marilde Cavuto, Monica Piersanti, Michele Fornaro, Giampaolo Perna, Alessandro Valchera, Monica Mazza, Felice Iasevoli, Giovanni Martinotti, Massimo Di Giannantonio

Journal Name: Current Clinical Pharmacology
Continued as Current Reviews in Clinical and Experimental Pharmacology

Volume 8 , Issue 3 , 2013


Schizophrenia is a chronic, severe and recurrent brain disorder that requires continuous, long-term treatment with antipsychotic medication to minimize relapse and provide clinical benefit to patients. For patients with schizophrenia, non-adherence to medication is a major risk factor for relapse and re-hospitalization. Long-acting injectable formulations of second-generation antipsychotics (SGAs-LAIs) provide constant medication delivery and the potential for improved adherence. Currently, three drugs are available for the treatment of schizophrenia, risperidone longacting injectable, olanzapine pamoate and paliperidone palmitate. Several studies have also demonstrated efficacy and safety of such drugs in patients with acute schizophrenia. In the present paper the literature on LAI atypical antipsychotics will be reviewed and practical advice will be given concerning the use of these drugs in the clinical practice.

Keywords: Adherence, efficacy, long-acting, olanzapine pamoate, paliperidone palmitate, risperidone long-acting, schizophrenia, second-generation antipsychotics, tolerability.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2013
Published on: 18 July, 2013
Page: [256 - 264]
Pages: 9
DOI: 10.2174/15748847113089990056
Price: $65

Article Metrics

PDF: 60