A New Multicomponent Protocol for the Synthesis of Pyridines and Fused Pyridines via a Formal aza [3+3] cycloaddition

Author(s): Giammarco Tenti, Mª Teresa Ramos, Jose Carlos Menendez

Journal Name: Current Organic Synthesis

Volume 10 , Issue 4 , 2013


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Abstract:

An efficient method for the synthesis of pyridines related to nicotinic acid and their fused derivatives is described. The overall process involves a sequence comprising a four-component reaction that creates the heterocyclic framework from very simple open-chain precursors and two elimination steps, that are performed without the need for purifying any intermediate.

Keywords: Multicomponent reactions, elimination reactions, heterocyclic synthesis, pyridines, quinolines.

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Article Details

VOLUME: 10
ISSUE: 4
Year: 2013
Page: [645 - 654]
Pages: 10
DOI: 10.2174/1570179411310040008
Price: $65

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