Abstract
Although it has become acceptable that neuroretinal cells are also affected in diabetes, vascular lesions continue to be considered as the hallmarks of diabetic retinopathy. Animal models are essential for the understanding and treatment of human diabetic retinopathy, and the mouse is intensively used as a model because of its similarity to human and the possibility to be genetically modified. However, until today not all retinal vascular lesions developed in diabetic patients have been reproduced in diabetic mice, and the reasons for this are not completely understood. In this review, we will summarize retinal vascular lesions found in diabetic and diabetic-like mouse models and its comparison to human lesions. The goal is to provide insights to better understand human and mice differences and thus, to facilitate the development of new mouse models that mimic better human diabetic retinopathy.
Keywords: Diabetes, retinopathy, microvascular complication, mouse model.
Current Medicinal Chemistry
Title:Mimicking Microvascular Alterations of Human Diabetic Retinopathy: A Challenge for the Mouse Models
Volume: 20 Issue: 26
Author(s): D. Ramos, A. Carretero, M. Navarro, L. Mendes-Jorge, V. Nacher, A. Rodriguez-Baeza and J. Ruberte
Affiliation:
Keywords: Diabetes, retinopathy, microvascular complication, mouse model.
Abstract: Although it has become acceptable that neuroretinal cells are also affected in diabetes, vascular lesions continue to be considered as the hallmarks of diabetic retinopathy. Animal models are essential for the understanding and treatment of human diabetic retinopathy, and the mouse is intensively used as a model because of its similarity to human and the possibility to be genetically modified. However, until today not all retinal vascular lesions developed in diabetic patients have been reproduced in diabetic mice, and the reasons for this are not completely understood. In this review, we will summarize retinal vascular lesions found in diabetic and diabetic-like mouse models and its comparison to human lesions. The goal is to provide insights to better understand human and mice differences and thus, to facilitate the development of new mouse models that mimic better human diabetic retinopathy.
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Cite this article as:
Ramos D., Carretero A., Navarro M., Mendes-Jorge L., Nacher V., Rodriguez-Baeza A. and Ruberte J., Mimicking Microvascular Alterations of Human Diabetic Retinopathy: A Challenge for the Mouse Models, Current Medicinal Chemistry 2013; 20 (26) . https://dx.doi.org/10.2174/09298673113209990028
DOI https://dx.doi.org/10.2174/09298673113209990028 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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