Modification and Functionalization of Carboxylated Multiwall Nanotubes with Amantadine, Pregabalin and Alendronate Using Amidation as Anti Cancer Derivatives

Author(s): Javad Azizian, Ehsan Ardestani, Mahdieh Entezari

Journal Name: Current Nanoscience

Volume 9 , Issue 4 , 2013

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In this study, multiwall carbon nanotubes (MWNTs) were modified and functionalized with Amantadine, Pregabalin and Alendronate. We investigated the formation of three anti cancer agents, functionalization on MWNTs, in addition to developing the amidation of MWNTs with amines. Functionalized carbon nanotubes were characterized by Fourier transform infrared (FT-IR), Raman, transmission electron microscopy (TEM), Ultra Violent spectroscopy (UV) and toxicity assay. Biological activity with human gastric cancer cells and MTT test for measurement of viable cell numbers were also performed.

Keywords: Functionalization, carboxylated multiwall carbon nanotubes, amantadine, pregabalin and alendronate.

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Article Details

Year: 2013
Published on: 30 June, 2013
Page: [442 - 446]
Pages: 5
DOI: 10.2174/1573413711309040004
Price: $65

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