Title:A Simple and Highly Efficient Procedure for One-Pot Synthesis of 2- Azetidinones Using 3,5-Dinitrobenzoyl Chloride
VOLUME: 10 ISSUE: 9
Author(s):Alireza Darvishi, Maaroof Zarei and Mohammad Reza Akhgara
Affiliation:Department of Chemistry, Faculty of Science, Kerman Branch, Islamic Azad University, Kerman, Iran; and Department of Chemistry, College of Sciences, Hormozgan University, Bandar Abbas 71961, Iran.
Keywords:β-Lactam, 2-Azetidinone, Staudinger reaction, 3, 5-Dinitrobenzoyl chloride, Ketene, Imine.
Abstract:One-pot synthesis of 2-azetidinones has efficiently been carried out in excellent yields by treatment of imines
and substituted acetic acids with 3,5-dinitrobenzoyl chloride in the presence of triethylamine. The method is remarkably
convenient and pure products were obtained by simple crystallization.
