An efficient and green one pot method is reported for regioselective synthesis of 1,4-disubstituted 1,2,3-
triazoles. In this method, β-ketoazides are generated via in situ reaction between α-bromo ketones and 1-butyl-3-
methylimidazolium azide [bmim]N3 in aqueous ethanol and reacted with terminal acetylenes using Cu-CuSO4 at room
temperature to afford 1,4-disubstituted 1,2,3-triazoles.
Keywords: α-Bromo ketones, 1-butyl-3-methylimidazolium azide, click reaction, copper-copper sulfate, cycloaddition, 1, 4-
disubstituted 1, 2, 3-triazoles, three component reaction.
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Published on: 26 November, 2013
Page: [738 - 743]