Title:A Passerini-Type Condensation: A Carboxylic Acid-Free Approach for the Synthesis of the α-Acyloxycarboxamides
VOLUME: 16 ISSUE: 10
Author(s):Mojtaba Mahyari, Shabnam Shaabani, Ahmad Shaabani and Seik Weng Ng
Affiliation:Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran.
Keywords:Isocyanide, Passerini reaction, α-acyloxycarboxamides.
Abstract:A Passerini-type condensation for the synthesis of α-acyloxycarboxamides starting from simple and readily
available inputs, including an isocyanide, aldehydes and water in the presence of trimethylsilyl azide as a catalyst under
reflux conditions in toluene in good yields, is described.