A Passerini-Type Condensation: A Carboxylic Acid-Free Approach for the Synthesis of the α-Acyloxycarboxamides

Title:A Passerini-Type Condensation: A Carboxylic Acid-Free Approach for the Synthesis of the α-Acyloxycarboxamides

VOLUME: 16 ISSUE: 10

Author(s):Mojtaba Mahyari, Shabnam Shaabani, Ahmad Shaabani and Seik Weng Ng

Affiliation:Faculty of Chemistry, Shahid Beheshti University, G. C., P. O. Box 19396-4716, Tehran, Iran.

Keywords:Isocyanide, Passerini reaction, α-acyloxycarboxamides.

Abstract:A Passerini-type condensation for the synthesis of α-acyloxycarboxamides starting from simple and readily available inputs, including an isocyanide, aldehydes and water in the presence of trimethylsilyl azide as a catalyst under reflux conditions in toluene in good yields, is described.

Cite this article as:

Mojtaba Mahyari, Shabnam Shaabani, Ahmad Shaabani and Seik Weng Ng, “A Passerini-Type Condensation: A Carboxylic Acid-Free Approach for the Synthesis of the α-Acyloxycarboxamides ”, Combinatorial Chemistry & High Throughput Screening (2013) 16: 858. https://doi.org/10.2174/13862073113169990051

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