A Passerini-Type Condensation: A Carboxylic Acid-Free Approach for the Synthesis of the α-Acyloxycarboxamides

Author(s): Mojtaba Mahyari, Shabnam Shaabani, Ahmad Shaabani, Seik Weng Ng

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 16 , Issue 10 , 2013

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A Passerini-type condensation for the synthesis of α-acyloxycarboxamides starting from simple and readily available inputs, including an isocyanide, aldehydes and water in the presence of trimethylsilyl azide as a catalyst under reflux conditions in toluene in good yields, is described.

Keywords: Isocyanide, Passerini reaction, α-acyloxycarboxamides.

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Article Details

Year: 2013
Published on: 18 November, 2013
Page: [858 - 864]
Pages: 7
DOI: 10.2174/13862073113169990051
Price: $65

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