Fast and Green One-Pot Multicomponent Synthesis of a Library of Pyrrolo[1,2-c] Pyrimidines Under Microwave Irradiation

Author(s): Emilian Georgescu, Florentina Georgescu, Constantin Draghici, Liliana Cristian, Marcel Mirel Popa, Florea Dumitrascu

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 16 , Issue 10 , 2013

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A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly.

Keywords: 1, 3-dipolar cycloaddition, microwaves, multicomponent reaction, N-ylide, pyrrolo[1, 2-c]pyrimidine.

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Article Details

Year: 2013
Page: [851 - 857]
Pages: 7
DOI: 10.2174/13862073113169990050
Price: $65

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