A simple, clean and rapid one-pot three component, microwave-assisted synthesis of pyrrolo[1,2-c]pyrimidine
derivatives starting from various substituted pyrimidines, 2-bromoacetophenones and nonsymmetrical, electron deficient
alkynes in 1,2-epoxybutane which acts both as solvent and acid scavenger is reported. This one-pot three component
synthesis implies short reaction times being at the same time highly cost-effective and environmental friendly.
Keywords: 1, 3-dipolar cycloaddition, microwaves, multicomponent reaction, N-ylide, pyrrolo[1, 2-c]pyrimidine.
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