Targeting mTOR: Evaluating the Therapeutic Potential of Resveratrol for Cancer Treatment

Author(s): Yan Wu, Feng Liu

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 13 , Issue 7 , 2013

Become EABM
Become Reviewer
Call for Editor


Resveratrol (3,4′,5-trihydroxystilbene; RSV), a natural polyphenol found in a variety of daily food including grapes and red wine, has long been suspected to have multifaceted health beneficial properties, including anti-inflammation, anti-oxidant, and anticancer activities. Over the past few years, numerous studies have suggested that suppressing the activity of mammalian target of rapamycin (mTOR), a critical regulator of cell metabolism, growth, and proliferation, may provide a key mechanism underlying the anticarcinogenic properties of resveratrol. It has been found that resveratrol targets multiple components of the phosphatidylinositol 3- kinase(PI3K)/Akt and mTOR signaling pathways, including PI3K, Akt, PTEN, and DEPTOR, suggesting that this natural compound and its derivatives may offer a promising new cancer treatment. In the current review, we discuss recent findings on the molecular mechanisms regulating mTOR signaling and the therapeutic potential of resveratrol for cancer treatment by targeting mTOR.

Keywords: Resveratrol, mTOR, PI3K/Akt, Cancer.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2013
Published on: 12 July, 2013
Page: [1032 - 1038]
Pages: 7
DOI: 10.2174/18715206113139990113
Price: $65

Article Metrics

PDF: 24