Efficacy of High-Dose Vitamin D Supplementation in the Critically Ill Patients

Author(s): Rachel M. Perron, Paul Lee

Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)
(Formerly Current Drug Targets - Inflammation & Allergy)

Volume 12 , Issue 4 , 2013


Vitamin D deficiency and its adverse skeletal sequelae are well recognized in the general population. Recent observation of high prevalence of low vitamin D states and their associations with worse clinical outcomes in critically ill populations have sparked interest in the role of supplementation for these patients. High-dose vitamin D efficaciously increases serum levels, but its impact on clinical outcome has not been examined. This article will review results from observational studies on prevalence and outcomes of hypovitaminosis D in critically ill patients, as well as caveats of vitamin D interventional trials. Improved understanding of vitamin D metabolism in critical illness will clarify the therapeutic potential of this pleiotropic hormone and facilitate implementation of cost-effective clinical trials.

Keywords: Critical illness, critically ill, high-dose supplementation, hypovitaminosis D, Vitamin D.

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Article Details

Year: 2013
Page: [273 - 281]
Pages: 9
DOI: 10.2174/18715281113129990047
Price: $58

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