Heterocycle-thioacetic Acid Motif: A Privileged Molecular Scaffold with Potent, Broad-Ranging Pharmacological Activities

Author(s): Yu’ning Song, Peng Zhan, Xinyong Liu

Journal Name: Current Pharmaceutical Design

Volume 19 , Issue 40 , 2013


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Abstract:

Privileged structures can bind to multiple targets with high affinity, thus aiding the discovery of novel bioactive agents. Heterocycle- thioacetic acid derivatives, a group of molecules containing a heterocycle core linked with a thioacetic acid-derived fragment, represent an important type of "privileged scaffold" possessing a wide spectrum of biological properties. Numerous encouraging investigations demonstratedthat this privileged structure should be extensively exploitedfor the therapeutic benefits. In view of its predominance, and on the basis of our research interest involved in this scaffold, an updated and detailed account of the pharmacological properties ofheterocycle-thioacetic acid derivatives is described in this article.

Keywords: Heterocycle-thioacetic acid, privileged scaffold, pharmacological activities, heterocycle, drug design.

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Article Details

VOLUME: 19
ISSUE: 40
Year: 2013
Published on: 09 December, 2013
Page: [7141 - 7154]
Pages: 14
DOI: 10.2174/13816128113199990505
Price: $65

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