In continuance of our search for anticonvulsant agents, we reported herein the synthesis, characterization and
anticonvulsant evaluation of some newer semicarbazone analogues. A few compounds were also screened for
neuroprotection assay. Some of the compounds showed significant anticonvulsant activity. Compound 4a showed 25%
(1/4, 0.25 h), 75% (3/4, 0.5 & 2.0 h) and 100% (4/4, 1.0 h) protection against 6 Hz psychomotor seizure test at 100 mg/kg
devoid of any neurotoxicity. Compound 4d showed neuroprotection activity with 26.3 ± 2.3 percent of total propidium
iodide uptake at 100 μM and IC50 of the compound was calculated using dose response curve by probit analysis and was
found to be 149 ± 1.22 μM.
Keywords: Anticonvulsant agents, 6 Hz psychomotor seizure test, Maximal electroshock seizure, Neurotoxicity, Semicarbazones.
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