Prosthetic devices in dentistry are commonly made of acrylic resin. This material has been continuously
improved and nanotechnology is now an important part of the process. The main objective of dentures is their restorative
function, while preventing the adherence of microorganisms present in the oral mucosa. Recently, nanopigments, fibers
and silver nanoparticles were incorporated into poly(methyl methacrylate) formulations, thus obtaining dental materials
with a reduced porosity, increased flexural strength and showing a lower Candida albicans adherence. The modified
acrylic resin was subjected to in vitro cytotoxicity and genotoxicity tests, resulting in a biocompatible option for denture
bases. The history, challenges, innovations and recent patents based on nanoparticles in prosthetic materials for dentures
are reviewed in this paper.