Breast cancer continues to be the second-leading cause of cancer in world. Early detection, improved surgical
techniques, and more effective therapy methods have improved quality of life and survival for patients, particularly those
with less advanced diseases. Therefore, tremendous amounts of time and efforts are dedicated to search toward earlier detection
and more efficient treatment of breast cancer. Advances in molecular cancer biology achieved an increased understanding
of the biologic factors that contribute to breast cancer pathogenesis and progression. This understanding has already
led to more effective treatment. Among different therapy modalities, nuclear medicine provides an important role to
the clinical management of breast cancer. In this review, the history of radioimmunotherapy of breast cancer as a targeted
molecular method is reviewed.