Title:One-pot Synthesis of Dihydropyrano[2,3-c]chromenes via a Three-component Reaction in Aqueous Media
VOLUME: 16 ISSUE: 10
Author(s):Saeed Balalaie, Ahmad Khazaie and Morteza Ashouriha
Affiliation:Peptide Chemistry Research Center, K. N. Toosi University of Technology, P. O. Box 15875-4416, Tehran, Iran.
Keywords:Aqueous media, Dihydropyrano[2, 3-c]chromenes, Natrium carbonate, One-pot three-component reaction,
Piperidine, Triethyl amine.
Abstract:An efficient protocol for the synthesis of dihydropyrano [2,3-c] chromenes derivatives by one-pot threecomponent
reaction of aromatic aldehydes, malononitrile or methyl cyanoacetate, and 4-hydroxy coumarin has been
developed using catalytic amount (10%) of three different catalysts piperidine, triethyl amine, and natrium carbonate in
aqueous media. The present protocol has significant features such as easy set-up and work-up, environmentally benign,
high yields, short reaction times.
