One-pot Synthesis of Dihydropyrano[2,3-c]chromenes via a Three-component Reaction in Aqueous Media

Author(s): Saeed Balalaie, Ahmad Khazaie, Morteza Ashouriha

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 16 , Issue 10 , 2013

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An efficient protocol for the synthesis of dihydropyrano [2,3-c] chromenes derivatives by one-pot threecomponent reaction of aromatic aldehydes, malononitrile or methyl cyanoacetate, and 4-hydroxy coumarin has been developed using catalytic amount (10%) of three different catalysts piperidine, triethyl amine, and natrium carbonate in aqueous media. The present protocol has significant features such as easy set-up and work-up, environmentally benign, high yields, short reaction times.

Keywords: Aqueous media, Dihydropyrano[2, 3-c]chromenes, Natrium carbonate, One-pot three-component reaction, Piperidine, Triethyl amine.

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Article Details

Year: 2013
Published on: 18 November, 2013
Page: [845 - 850]
Pages: 6
DOI: 10.2174/1386207311301010005
Price: $65

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