Selected ion flow tube mass spectrometry (SIFT-MS) has been applied to determine the concentration of selected
metabolites in exhaled breath in five patients before and after gastro-oesophageal cancer surgery. Eight metabolites
for exhaled breath stored in Nalophan® bags were specifically investigated using H3O+ and NO+ in the Multiple Ion Mode
(MIM) of the SIFT-MS. No significant change is observed for propanol and acetic acid. Metabolites mean values are
found to increase for acetone and hexanoic acid in patients after surgery; ammonia, ethanol, hydrogen cyanide and isoprene
are found to decrease in the same patients. Mann-Whitney U test is also conducted for these eight metabolites in exhaled
breath samples before and after recovery from surgery. Hexanoic acid (p = 0.009) and isoprene (p = 0.016) are
found to be statistically significantly different. This study demonstrates SIFT-MS to be a promising technique applicable
in a clinical setting for the analysis of exhaled breath metabolites in patients with gastro-oesophageal cancer.
Keywords: SIFT-MS, breath analysis, gastro-oesophageal cancer.
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Published on: 30 June, 2013
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