Ascorbic acid-Catalyzed One-Pot Three-Component Biginelli Reaction: A Practical and Green Approach towards Synthesis of 3,4-dihydropyrimidin- 2(1H)-ones/thiones

Author(s): Imene Sehout, Raouf Boulcina, Boudjemaa Boumoud, Fabienne Berree, Bertrand Carboni, Abdelmadjid Debache

Journal Name: Letters in Organic Chemistry

Volume 10 , Issue 7 , 2013

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An efficient one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones via a three-component Biginelli condensation of aldehyde, ethyl acetoacetate, and urea or thiourea in the presence of a catalytic amount of ascorbic acid (5 mol %) is described. The reaction proceeded efficiently under solvent-free conditions at 80 °C to afford the desired products in moderate to good yields.

Keywords: Multicomponent reaction; one-pot synthesis; Biginelli reaction; 3, 4dihydropyrimidin-2(1H)-ones/thiones; ascorbic acid.

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Article Details

Year: 2013
Published on: 30 June, 2013
Page: [463 - 467]
Pages: 5
DOI: 10.2174/15701786113109990014
Price: $65

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