Objective: We report a case of acute interstitial nephritis (AIN) and immune hemolytic anemia (IHA)
associated with cefpodoxime therapy.
Case Summary: A patient with a recent history of cefpodoxime proxetil treatment presented with elevated serum
creatinine, oliguria, nausea, vomiting, and dyspnea. Evidence of renal failure, abnormal urinalysis, and renal biopsy with
inflammatory infiltrate in the interstitium confirmed a diagnosis of AIN. The patient subsequently developed IHA, which
was confirmed by peripheral blood smear results and positive Coombs’ test. The patient recovered after dialysis therapy
and 2 days of intravenous methylprednisolone (500mg/day) followed by oral prednisolone (60 mg/day), which was
rapidly tapered and stopped within 3 weeks.
Conclusions: To our knowledge, cefpodoxime-induced AIN and IHA are unprecedented. Physicians should be aware that
drug-induced AIN and hemolysis can be associated with cefpodoxime proxetil.