Catalyst / Surfactant Free Chemoselective Acylation of Amines in Water

Title:Catalyst / Surfactant Free Chemoselective Acylation of Amines in Water

Volume: 1 Issue: 1

Author(s): Balakrishna Dulla, Suryadevara Vijayavardhini, Dandela Rambau, Vegendla Anuradha, Mandava V.B. Rao and Manojit Pal

Affiliation:

Keywords: Acylation, amines, anhydrides, water.

Abstract: Chemoselective acylation of amines has been carried out in water under open air using acyclic or cyclic anhydrides or benzoyl chloride in the absence of any acid or base catalyst or a surfactant. The alkyl or aryl amines including primary or secondary amines, amino acids, diamines etc afforded the corresponding N-acyl derivatives in good yields. The selective N-acylation was observed in the presence of -OH, -SH, -COOH or -COOEt group. Being a practical alternative to the existing methods for selective acylation of amines the present methodology may find applications.

Cite this article as:

Dulla Balakrishna, Vijayavardhini Suryadevara, Rambau Dandela, Anuradha Vegendla, Rao V.B. Mandava and Pal Manojit, Catalyst / Surfactant Free Chemoselective Acylation of Amines in Water, Current Green Chemistry 2014; 1 (1) . https://dx.doi.org/10.2174/22133461114019990002