Modulation of Inflammatory Response Improves Myocardial Infarct Healing in Rats

Author(s): A.P. Sarapultsev, O.N. Chupakhin, P.A. Sarapultsev, M.A. Rantsev, S.U. Medvedeva, L.P. Sidorova, M.T. Abidov, I.G. Danilova

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 12 , 2014

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Abstract:

It is reputed that the ideal therapeutic approaches to treatment of patients with acute coronary syndrome (ACS) and myocardium infarction (MI) should be aimed at the inflammation reaction triggers. This study investigated the effectiveness of the impact of L- 17 compound of the group of 5- phenyl substituted-6H-1,3,4-thiadiazine-2-amines upon the course of experimental MI as compared to the impact of a preparation, officially registered in Russia as an immunomodulator, Tamerit, belonging to phthalhydrazid derivative substance. Acute MI in rats was induced by left coronary artery coagulation. Histological study of the myocardium sections and biochemical analysis has been carried out at the 1st and 7th days of the experimental MI. The conducted investigations have shown that under the action of immunocorrectors the inflammation reaction character changes, exudative/destructive inflammation is replaced by a proliferativecellular one. Animals’ blood biochemical analysis at the background of L-17 and Tamerit introduction has shown a decrease of aminotransferases and lactatedehydrogenases activity in blood as compared to the reference group of animals’ indicators, which is evidently caused by epicardial injury of myocardium and lesser amount of the alternative cardiomyocytes. At the same time, no noticeable difference in biochemical characteristics in groups, having been treated to immunomodulators of different chemical composition was identified, which is the sign of the essential similarity of their impact. Thus, immunocorrectors of different chemical groups (Tamerit and compound L17) diminish the volume of initial myocardial infarction and accelerate the granulation processes in course of MI, and represent a new category of treatment agents.

Keywords: Inammation, L-17 compound, myocardial infarction, Tamerit, thiadiazine-2 amines, sodium nucleinate.

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Article Details

VOLUME: 20
ISSUE: 12
Year: 2014
Page: [1980 - 1986]
Pages: 7
DOI: 10.2174/13816128113199990492
Price: $65

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