Diagnosis and Treatment of Unilateral Forms of Primary Aldosteronism

Author(s): Andrea Viola, Davide Tizzani, Silvia Monticone, Valentina Crudo, Maddalena Galmozzi, Jacopo Burrello, Karine Versace, Maria Loiacono, Franco Veglio, Paolo Mulatero

Journal Name: Current Hypertension Reviews

Volume 9 , Issue 2 , 2013

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Primary aldosteronism (PA) is now recognized as the most frequent form of secondary arterial hypertension. The importance of a correct and prompt diagnosis of PA is determined by its relevant prevalence, its increased cardiovascular risk compared to essential hypertension and by the possibility of reversing this increased risk with a targeted therapy. Surgical treatment of unilateral forms of PA (mainly aldosterone-producing adenomas) is at present recommended in well-selected patients because of its cost-effectiveness. Therefore, subtype differentiation of PA forms is of fundamental importance, and available guidelines recommend contrast-enhanced CT-scanning and adrenal venous sampling (AVS) as the main diagnostic tests for this purpose. In this review, we discuss the value of adrenal non-invasive imaging and AVS, the recent advances in complementary tests and, finally, the available data on the outcome of surgical treatment for PA.

Keywords: Adrenal vein sampling, aldosterone, aldosterone-producing adenoma, familial hyperaldosteronism, endocrine hypertension, primary aldosteronism.

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Article Details

Year: 2013
Page: [156 - 165]
Pages: 10
DOI: 10.2174/15734021113099990008
Price: $65

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