Synthetic Applications of γ-Hydroxybutenolides

Author(s): William H. Miles

Journal Name: Current Organic Synthesis

Volume 11 , Issue 2 , 2014

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Graphical Abstract:


γ-Hydroxybutenolides are readily available reagents that are useful starting materials for the synthesis of simple and complex compounds. This review will discuss the role tautomerism plays in the reactivity profile of γ-hydroxybutenolides, the major modes of reactivity of γ-hydroxybutenolides, and the application of this methodology for the synthesis of biologically important molecules.

Keywords: Diels-Alder reaction, Grignard reaction, γ-hydroxybutenolides, oxidation, reduction, synthesis, tautomerism.

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Article Details

Year: 2014
Page: [244 - 267]
Pages: 24
DOI: 10.2174/15701794113109990062
Price: $65

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PDF: 28