Synthesis of a Novel Class of gem-Phosphonate-Phosphates by Reductive Cleavage of the Isoxazolidine Ring

Author(s): Olga Bortolini, Iqbal Mulani, Antonio De Nino, Loredana Maiuolo, Alessandro Melicchio, Beatrice Russo, Donatella Granchi

Journal Name: Current Organic Synthesis

Volume 11 , Issue 3 , 2014

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Graphical Abstract:


A new series of gem-phosphonate-phosphates bearing N-alkyl groups and aromatic substituents has been prepared by reductive cleavage of the isoxazolidine ring with metal carbonyls, using the gem-phosphonate-phosphate rearrangement.

Keywords: Apolipoprotein E, bisphosphonates, gem-phosphonate-phosphate rearrangement, isoxazolidines, ring opening, transition-metal carbonyls.

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Article Details

Year: 2014
Page: [461 - 465]
Pages: 5
DOI: 10.2174/15701794113109990061
Price: $65

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PDF: 17