Amylin (islet amyloid polypeptide) and amyloid beta protein (Aβ), identified as proteinaceous deposits within
the pancreas of diabetics and the brain of Alzheimer’s patients respectively, share many biophysical, physiological and
neurotoxic properties. Although no specific “Aβ receptor” has been identified, emerging evidence suggests that the
amylin receptor serves a putative target receptor for the actions of Aβ in the brain. The amylin receptor consists of a calcitonin
receptor dimerized with receptor activity-modifying proteins and is widely distributed within central nervous system.
Aβ can directly activate this G protein-coupled receptor and trigger multiple intracellular signal transduction messengers
and pathways that include calcium, cAMP, ERK1/2 and Fos. Growing evidence suggests that amylin and amylin
receptors are involved in many aspects of neurodegenerative pathophysiology. Developing therapeutic strategies aimed at
modulating amylin receptor function may prove useful for treatment of neurodegenerative diseases such as Alzheimer’s
Keywords: Alzheimer’s disease, amyloid β (Aβ) protein, calcitonin receptor, calcitonin gene related peptide, diabetes mellitus,
human amylin, receptor activity-modifying proteins.
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