The synthesis of novel compound libraries along with screening is a rapid and effective approach for the
discovery of potential chemical agents, and it becomes an important method in pharmaceutical chemistry research. 1,3,4-
oxadiazole derivatives as the typical heterocyclic compounds, exhibit a broad spectrum of biological activities and vital
leading compounds for the development of chemical drugs. Herein, we focus on the synthesis and screening of novel
1,3,4-oxadiazoles derivatives with antimicrobial, antitumor or antiviral activities during the past decade. In this review,
we discussed the synthetic development of 1,3,4-oxadiazoles derivatives, and also the relevant bioactivity and their
prospects as the potential chemical drugs.