A Dual Role for Sirtuin 1 in Tumorigenesis

Author(s): Yujiang Fang, Michael B. Nicholl

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 15 , 2014

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Abstract:

Sirtuin 1 (SIRT1) is an NAD+-dependent histone deacetylase which regulates many normal physiological and pathological processes. In addition to its place in cellular energy metabolism, increasing evidence shows a role for SIRT1 in tumorigenesis, wherein it can function as either a tumor promoter or suppressor. Its function in malignancy varies with concentration, cellular location, temporal and spatial distribution, and regulation by upstream and downstream factors. In this mini-review, we present the existing data which implicates SIRT1 in tumorigenesis.

Keywords: Sirtuin1, tumor.

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Article Details

VOLUME: 20
ISSUE: 15
Year: 2014
Page: [2634 - 2636]
Pages: 3
DOI: 10.2174/13816128113199990488
Price: $65

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