Title:A Dual Role for Sirtuin 1 in Tumorigenesis
VOLUME: 20 ISSUE: 15
Author(s):Yujiang Fang and Michael B. Nicholl
Affiliation:Department of Surgery, University of Missouri, One Hospital Drive, MC520E, DC116.94, Columbia, MO 65212, USA.
Keywords:Sirtuin1, tumor.
Abstract:Sirtuin 1 (SIRT1) is an NAD+-dependent histone deacetylase which regulates many normal physiological and pathological
processes. In addition to its place in cellular energy metabolism, increasing evidence shows a role for SIRT1 in tumorigenesis, wherein it
can function as either a tumor promoter or suppressor. Its function in malignancy varies with concentration, cellular location, temporal
and spatial distribution, and regulation by upstream and downstream factors. In this mini-review, we present the existing data which implicates
SIRT1 in tumorigenesis.
