Glutamine, Glucose and other Fuels for Cancer

Author(s): Maria Victoria Ruiz-Perez, Francisca Sanchez-Jimenez, Francisco J. Alonso, Juan A. Segura, Javier Marquez, Miguel Angel Medina

Journal Name: Current Pharmaceutical Design

Volume 20 , Issue 15 , 2014

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Abstract:

Tumor cells suffer a metabolic reprogramming which allows them to use metabolic fuels (glucose, glutamine, lipids) through anabolic fates to support their enhanced proliferation and other carcinogenesis-related features. The present review tries to address and summarize the broad and growing information available about this reprogramming, whose pieces, put together, make up a complex scheme that encompasses different complexity scales, from cells to systemic networks.

Keywords: Aerobic glycolysis, cancer metabolism, glutaminolysis, metabolic reprogramming, tumor microenvironment.

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Article Details

VOLUME: 20
ISSUE: 15
Year: 2014
Page: [2557 - 2579]
Pages: 23
DOI: 10.2174/13816128113199990482
Price: $65

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