Title:An Up-date of Olive Oil Phenols in Inflammation and Cancer: Molecular Mechanisms and Clinical Implications
VOLUME: 20 ISSUE: 37
Author(s):A. Cárdeno, M. Sánchez-Hidalgo and C. Alarcón-de-la-Lastra
Affiliation:Department of Pharmacology, Faculty of Pharmacy, University of Seville, Spain
Keywords:Cancer, inflammation, olive oil, oxidative stress, phenols.
Abstract:Olive oil (OO), the main fatty component of the Mediterranean diet, exhibits numerous biological functions
which are beneficial for the state of health. In addition to monounsaturated fatty acid (MUFA) evidences have accumulated
on the favorable properties of its minor though highly bioactive components, particularly the phenolic compounds,
which have shown a broad spectrum of bioactive properties, including antioxidant and anti-inflammatory effects both associated
with the origin of the main chronic diseases. Additional studies have demonstrated that the health effects of olive
oil polyphenols have been also associated with their, neuroprotective, antiaging and antiatherogenic effects. On the other
hand, because of their ability to modulate cell death, olive polyphenols have been proposed as chemopreventive and
therapeutic agents. Thus, the purpose of this article is to review the chemistry, bioavailability and pharmacokinetic characteristics
of OO polyphenols, in addition to provide the reader an up-date of their putative antioxidant, anti-inflammatory
and anti-cancer activities as well as the plausible action mechanisms involved.
