Drug-Delivery Systems of Green Tea Catechins for Improved Stability and Bioavailability

Author(s): C. F. Rodrigues, K. Ascenção, F. A.M. Silva, B. Sarmento, M. B.P.P. Oliveira, J. C. Andrade

Journal Name: Current Medicinal Chemistry

Volume 20 , Issue 37 , 2013

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Numerous studies in humans, animal models and cell lines have suggested the potential benefits from the consumption of green tea polyphenols, including prevention of cancer and heart diseases. However these potential effects have been strongly limited by green tea catechins low bioavailability, which hinders the development of therapeutic applications. In this review formulations that are being proposed for delivery of green tea catechins are discussed. New delivery systems are presented as valid alternatives to overcome the limitations such as green tea catechins poor stability or intestinal absorption.

Keywords: Antioxidant, drug delivery, epigallocatechin-3-gallate, green tea polyphenols, catechins, EGCG.

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Article Details

Year: 2013
Page: [4744 - 4757]
Pages: 14
DOI: 10.2174/09298673113209990158
Price: $65

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PDF: 46