A series of novel analogues of 1,3-diarylprop-2-en-1-one (3a-m) were synthesized and evaluated for their inhibitory
activity of FOX P3 gene expression and apoptosis in CD4+T cells that had been isolated from the spleen of 8 to
10 weeks old mice. The structure-activity relationship (SAR) of the R1 and R2 modification was studied to identify a candidate
with the maximum potency. Of these compounds, 3d showed the highest inhibitory activity of FOX P3 gene expression
and apoptosis (66.5 % inhibition at 10 μM). To the best of the authors’ knowledge this is the first report of 1,3-
diarylprop-2-en-1-ones as regulators of FOX P3 gene expression.
Keywords: 1, 3-Diarylprop-2-en-1-one, pyrazole, FOX P3, anti-cancer.
Rights & PermissionsPrintExport