Abstract
Among the contingency of methodologies available for bioconjugation, the Click dipolar [3+2] cycloaddition pathway that results in the formation of triazole linkage were extensively investigated during the last few years in a wide variety of molecular architectures – that ranges between small molecules and polymers. Synthetic feasibility as well as the stability and application of triazole linkage were explored and successfully accomplished in live cells, in vitro, in vivo and tissues. The objective of this review is to present recent reports of this synthetic methodology, as applied to oligonucleotide chemistry. Advances in development of Click solid supports, newer alkyne and azide building blocks, covalent conjugations at either termini (3',5'), internal sites (base, sugar and backbone), solid and solution-phase labeling strategies, and applications to oligonucleotide detection are summarized in this review.
Keywords: Click chemistry, Click reactions, Nucleosides, Nucleotides and oligonucleotides labeling, Cycloaddition reactions.
Current Organic Chemistry
Title:Click Chemistry Based Functionalizations of Nucleoside, Nucleotide and Nucleic Acids
Volume: 17 Issue: 19
Author(s): Anilkumar R. Kore and Irudaya Charles
Affiliation:
Keywords: Click chemistry, Click reactions, Nucleosides, Nucleotides and oligonucleotides labeling, Cycloaddition reactions.
Abstract: Among the contingency of methodologies available for bioconjugation, the Click dipolar [3+2] cycloaddition pathway that results in the formation of triazole linkage were extensively investigated during the last few years in a wide variety of molecular architectures – that ranges between small molecules and polymers. Synthetic feasibility as well as the stability and application of triazole linkage were explored and successfully accomplished in live cells, in vitro, in vivo and tissues. The objective of this review is to present recent reports of this synthetic methodology, as applied to oligonucleotide chemistry. Advances in development of Click solid supports, newer alkyne and azide building blocks, covalent conjugations at either termini (3',5'), internal sites (base, sugar and backbone), solid and solution-phase labeling strategies, and applications to oligonucleotide detection are summarized in this review.
Export Options
About this article
Cite this article as:
Kore R. Anilkumar and Charles Irudaya, Click Chemistry Based Functionalizations of Nucleoside, Nucleotide and Nucleic Acids, Current Organic Chemistry 2013; 17 (19) . https://dx.doi.org/10.2174/13852728113179990030
DOI https://dx.doi.org/10.2174/13852728113179990030 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
IP6 in Cancer Therapy: Past, Present and Future
Current Cancer Therapy Reviews Functional Improvement of Chimeric Antigen Receptor Through Intrinsic Interleukin-15Rα Signaling
Current Gene Therapy Therapeutic Potential of Hammerhead Ribozymes in the Treatment of Hyper-Proliferative Diseases
Current Pharmaceutical Biotechnology Meet Our Editorial Board Member
Current Stem Cell Research & Therapy Tumor Growth-Promoting Properties of Macrophage Migration Inhibitory Factor
Current Pharmaceutical Design Methylation of ZNF331 Promotes Cell Invasion and Migration in Human Esophageal Cancer
Current Protein & Peptide Science Targeted Angiogenesis Therapy in Head and Neck Squamous Cell Carcinomas
Current Angiogenesis (Discontinued) HER-2 Signaling and Inhibition in Breast Cancer
Current Cancer Drug Targets Entropy and Enthalpy in the Activity of Tubulin-Based Antimitotic Agents
Current Chemical Biology TGF-β in Epithelial to Mesenchymal Transition and Metastasis of Liver Carcinoma
Current Pharmaceutical Design In-Silico Algorithms for the Screening of Possible microRNA Binding Sites and Their Interactions
Current Genomics Metabolic Profiling in Disease Diagnosis, Toxicology and Personalized Healthcare
Current Pharmaceutical Biotechnology Pro-Oncogenic Cell Signaling Machinery as a Target for Oncolytic Viruses
Current Pharmaceutical Biotechnology Recent Advances in the Development of Dual Topoisomerase I and II Inhibitors as Anticancer Drugs
Current Medicinal Chemistry Progress in Immunotherapy of Head and Neck Squamous Cell Carcinoma
Current Molecular Pharmacology Targeting Prenylated RAS Modifying Enzymes in Cancer Cells
Current Signal Transduction Therapy The Cooperative Effect between Polybasic Region (PBR) and Polysialyltransferase Domain (PSTD) within Tumor-Target Polysialyltranseferase ST8Sia II
Current Topics in Medicinal Chemistry Alam K et al. (2018) Drug Metabolism Letters; 12, 24-32.
Drug Metabolism Letters Managing Multi-Center Recruitment in the PLCO Cancer Screening Trial
Reviews on Recent Clinical Trials Biochemical and Pharmaceutic Properties of Genus <i>Phyllanthus</i> spp.: Focus on <i>P. amarus</i> Schum. & Thonn. and <i>P. niruri</i> L.
Current Traditional Medicine